Accurate ranking of differentially expressed genes by a distribution-free shrinkage approach.

Abstract

High-dimensional case-control analysis is encountered in many different settings in genomics. In order to rank genes accordingly, many different scores have been proposed, ranging from ad hoc modifications of the ordinary t statistic to complicated hierarchical Bayesian models. Here, we introduce the "shrinkage t" statistic that is based on a novel and… (More)

Cite this paper

@article{OpgenRhein2007AccurateRO, title={Accurate ranking of differentially expressed genes by a distribution-free shrinkage approach.}, author={Rainer Opgen-Rhein and Korbinian Strimmer}, journal={Statistical applications in genetics and molecular biology}, year={2007}, volume={6}, pages={Article9} }