Accurate mass measurement of DNA oligonucleotide ions using high-resolution time-of-flight mass spectrometry.

@article{Koomen2002AccurateMM,
  title={Accurate mass measurement of DNA oligonucleotide ions using high-resolution time-of-flight mass spectrometry.},
  author={John M Koomen and William K. Russell and Shane E. Tichy and David H Russell},
  journal={Journal of mass spectrometry : JMS},
  year={2002},
  volume={37 4},
  pages={357-71}
}
Matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) time-of-flight mass spectrometry (TOFMS) play an essential role in the analysis of biological molecules, not only peptides and proteins, but also DNA and RNA. Tandem mass spectrometry used for sequence analysis has been a major focus of technological developments in mass spectrometry, but accurate mass measurements by high-resolution TOFMS are equally important. This paper describes the role that high mass… CONTINUE READING
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