Accurate eGFR reporting for children without anthropometric data.

  title={Accurate eGFR reporting for children without anthropometric data.},
  author={Emil den Bakker and R. Gemke and J. V. van Wijk and I. Hubeek and B. Stoffel‐Wagner and A. Grubb and A. B{\"o}kenkamp},
  journal={Clinica chimica acta; international journal of clinical chemistry},
INTRODUCTION Reporting estimated glomerular filtration rate (eGFR) instead of serum concentrations is advised in current guidelines. Most creatinine-based eGFR equations for children require height, a parameter not readily available to laboratories. Combining height-dependent creatinine- and cystatin C-based eGFR improves performance. Recently, a height-independent creatinine-based eGFR equation has been developed. AIM To compare the combination of height-independent creatinine- and cystatin… Expand
Combining GFR estimates from cystatin C and creatinine—what is the optimal mix?
In the absence of height data, the optimal strategy for estimating GFR in children is by using the geometric mean of FASage and FAScys, and when there is large disagreement between the two, weighted means based on diagnosis improve accuracy. Expand
Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations
The SchwartzcysC equation is a good height-independent alternative to the SchwartzCKiD equation in children and can be reported directly by the laboratory information system. Expand
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children
The present study strongly suggests that cystatin C should be the primary biomarker of choice when estimating GFR in children with decreased GFR and arithmetic means of well-performing single-marker equations improve accuracy at most mGFR levels and have practical advantages compared to composite equations. Expand
A novel method for creatinine adjustment makes the revised Lund–Malmö GFR estimating equation applicable in children
Abstract The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adultExpand
Estimation of the glomerular filtration rate in children and young adults using the CKD-EPI equation with age-adjusted creatinine values.
CKD-EPI with age-adjusted creatinine instead of actual age and creat inine led to extensive improvements in bias, precision, and accuracy at all ages, in both sexes and at all levels of GFR. Expand
Estimation of GFR in children using rescaled beta-trace protein.
Rescaled BTP concentrations are a simple method for estimating GFR in children and the additional value of BTP for the estimation of GFR compared to rescaled creatinine and cystatin C still remains to be demonstrated. Expand
Endogenous markers for kidney function in children: a review
An in-depth review of the physiology, measurement and clinical use of creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin in children and the generation of eGFR equations in children is addressed. Expand
Evidence for shrunken pore syndrome in children
A definition based on eGFRcys/eGFRcrea/exogenous clearance study may be useful to study the effect of SPS on creatinine metabolism, suggesting glomerular pore size as a common denominator. Expand
Glomerular filtration and shrunken pore syndrome in children and adults
The use of cystatin C (13 kDa) as a marker of GFR has allowed the discovery that the filtration of 5–30 kDa molecules can be selectively impaired defining the shrunken pore syndrome. Expand


A simple height-independent equation for estimating glomerular filtration rate in children
A height-independent eGFR equation based on the concept of a population-normalized Scr, presented before for adults, is extended to children and should make (mass) screening of kidney function in children easier. Expand
Height-independent estimation of glomerular filtration rate in children: an alternative to the Schwartz equation.
The performance of eGFR-Pottel is superior to that of e GFR-BCCH and comparable with that of eG FR-Schwartz, and could be reported by the laboratory if height data are not available. Expand
Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables diagnosing Shrunken Pore Syndrome
Abstract Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows atExpand
Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C
A new GFR estimating equation works well in children with CKD in a range of GFR from 15 to 75 ml/min per 1.73 m2 and is needed to establish the applicability to children of normal stature and muscle mass, and higher GFR. Expand
Estimating glomerular filtration rate from serum creatinine and cystatin C.
The combined creatinine-cystatin C equation performed better than equations based on either of these markers alone and may be useful as a confirmatory test for chronic kidney disease. Expand
Improved GFR estimation by combined creatinine and cystatin C measurements.
The estimated GFR combining Pcr and cysC measurements more accurately matched the reference GFR at all stages of CKD than the other equations, particularly in patients with near-normal kidney function. Expand
Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden
Combining cystatin C and creatinine assays improves GFR estimations with P30 ≥90% in adults, and the combined equations had a more stable performance across mGFR, age and BMI intervals. Expand
Precision of estimating equations for GFR in children with a solitary functioning kidney: the KIMONO study.
Use of a combined serum cystatin C/creatinine-based equation (eGFR-CKiD2) is recommended to monitor renal function in children with a solitary functioning kidney and when cyStatin C is not routinely available, eG FR-Schwartz should be used. Expand
A Comparison of GFR estimating formulae based upon s-cystatin C and s-creatinine and a combination of the two.
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Estimating GFR using formulae based on s-creatinine or s-cystatin C alone was equally accurate according to the NKF K/DOQI guidelines and a formula that combines both provided a greater accuracy. Expand
Improved estimation of glomerular filtration rate (GFR) by comparison of eGFRcystatin C and eGFRcreatinine
Comparison of the agreement between eGFRcystatin C and eG FRcreatinine can be used to evaluate the diagnostic performance of combined cystatinC- and creatinine-based estimations of GFR, and if ‘threshold values’ for discordance are exceeded whether the clinical context requires the use of an invasive gold standard method to measure GFR. Expand