Accurate determination of human serum transferrin isoforms: Exploring metal-specific isotope dilution analysis as a quantitative proteomic tool.

@article{Busto2006AccurateDO,
  title={Accurate determination of human serum transferrin isoforms: Exploring metal-specific isotope dilution analysis as a quantitative proteomic tool.},
  author={Maria Estela Del Castillo Busto and M Montes-Bay{\'o}n and Alfredo Sanz-Medel},
  journal={Analytical chemistry},
  year={2006},
  volume={78 24},
  pages={
          8218-26
        }
}
Carbohydrate-deficient transferrin (CDT) measurements are considered a reliable marker for chronic alcohol consumption, and its use is becoming extensive in forensic medicine. However, CDT is not a single molecular entity but refers to a group of sialic acid-deficient transferrin isoforms from mono- to trisialotransferrin. Thus, the development of methods to analyze accurately and precisely individual transferrin isoforms in biological fluids such as serum is of increasing importance. The… CONTINUE READING