Accurate detection of differential RNA processing

  title={Accurate detection of differential RNA processing},
  author={Philipp Drewe and Oliver Stegle and Lisa Hartmann and Andr{\'e} Kahles and Regina Bohnert and Andreas Wachter and Karsten M. Borgwardt and Gunnar Raetsch},
  booktitle={Nucleic acids research},
Deep transcriptome sequencing (RNA-Seq) has become a vital tool for studying the state of cells in the context of varying environments, genotypes and other factors. RNA-Seq profiling data enable identification of novel isoforms, quantification of known isoforms and detection of changes in transcriptional or RNA-processing activity. Existing approaches to detect differential isoform abundance between samples either require a complete isoform annotation or fall short in providing statistically… CONTINUE READING
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