Accurate detection of SNPs using base-specific cleavage and mass spectrometry


Accurate detection of single-nucleotide polymorphisms (SNPs) is crucial for the success of many downstream analyses such as clinical diagnosis, virus identification, genetic mapping and association studies. Among many others, one valuable approach for SNP detection is based on the base-specific cleavage of single-stranded nucleic acids followed by matrix… (More)
DOI: 10.1109/BIBM.2012.6392727

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