Accurate and Scalable Techniques for the Complex/Pathway Membership Problem in Protein Networks

@inproceedings{amoglu2009AccurateAS,
  title={Accurate and Scalable Techniques for the Complex/Pathway Membership Problem in Protein Networks},
  author={Orhan Çamoglu and Tolga Can and Ambuj K. Singh},
  booktitle={Adv. Bioinformatics},
  year={2009}
}
A protein network shows physical interactions as well as functional associations. An important usage of such networks is to discover unknown members of partially known complexes and pathways. A number of methods exist for such analyses, and they can be divided into two main categories based on their treatment of highly connected proteins. In this paper, we show that methods that are not affected by the degree (number of linkages) of a protein give more accurate predictions for certain complexes… CONTINUE READING

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