Accurate activity measurement of Lu-177 by the liquid scintillation 4πβ-γ coincidence counting technique.

Abstract

This paper reports on absolute measurements made at the NMISA by the 4π[LS]β-γ coincidence extrapolation technique, which formed part of a key comparison of activity measurements of the radionuclide lutetium-177, a beta-gamma emitter. A detection efficiency analysis based on the decay scheme indicated that the coincidence extrapolation method is feasible for extracting the source disintegration rate of (177)Lu. A simulation was undertaken utilizing the efficiency equations to give an indication of the expected variation of the source count rate with efficiency for different gamma-ray windows. Both the simulation and experiment indicated that the window giving the highest counting efficiency was centered about the 208.4 keV photopeak, with the data showing linear variation in the upper efficiency range. The extracted activity concentration of the (177)Lu solution proved to be highly accurate, being higher than the proposed comparison reference value by 0.15%, well within one standard uncertainty (σ=0.26%) as specified by the NMISA.

DOI: 10.1016/j.apradiso.2012.02.102

Cite this paper

@article{Simpson2012AccurateAM, title={Accurate activity measurement of Lu-177 by the liquid scintillation 4πβ-γ coincidence counting technique.}, author={B R S Simpson and M J van Staden and J Lubbe and W M van Wyngaardt}, journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine}, year={2012}, volume={70 9}, pages={2209-14} }