Accurate Reconstruction of Insertion-Deletion Histories by Statistical Phylogenetics

Abstract

The Multiple Sequence Alignment (MSA) is a computational abstraction that represents a partial summary either of indel history, or of structural similarity. Taking the former view (indel history), it is possible to use formal automata theory to generalize the phylogenetic likelihood framework for finite substitution models (Dayhoff's probability matrices… (More)
DOI: 10.1371/journal.pone.0034572

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