Accurate Prediction of the Response of Freshwater Fish to a Mixture of Estrogenic Chemicals

@inproceedings{Brian2005AccuratePO,
  title={Accurate Prediction of the Response of Freshwater Fish to a Mixture of Estrogenic Chemicals},
  author={Jayne V. Brian and Catherine A. Harris and Martin Scholze and Thomas Backhaus and Petra Booy and Marja H. Lamoree and Giulio Pojana and Niels Jonkers and Tamsin J. Runnalls and Angela Bonf{\`a} and Antonio Marcomini and John P. Sumpter},
  booktitle={Environmental health perspectives},
  year={2005}
}
Existing environmental risk assessment procedures are limited in their ability to evaluate the combined effects of chemical mixtures. We investigated the implications of this by analyzing the combined effects of a multicomponent mixture of five estrogenic chemicals using vitellogenin induction in male fathead minnows as an end point. The mixture consisted of estradiol, ethynylestradiol, nonylphenol, octylphenol, and bisphenol A. We determined concentration-response curves for each of the… CONTINUE READING
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