Accurate Genetic Detection of Hepatitis C Virus Transmissions in Outbreak Settings.

@article{Campo2016AccurateGD,
  title={Accurate Genetic Detection of Hepatitis C Virus Transmissions in Outbreak Settings.},
  author={David S. Campo and Guo-liang Xia and Zoya E. Dimitrova and Yulin Lin and Joseph C. Forbi and Lilia Milkova Ganova-Raeva and Lili Punkova and Sumathi Ramachandran and Hong Thai and Pavel Skums and Seth Sims and Inna Rytsareva and Gilberto Vaughan and Ha-Jung Roh and Michael A Purdy and Amanda Sue and Y. Khudyakov},
  journal={The Journal of infectious diseases},
  year={2016},
  volume={213 6},
  pages={
          957-65
        }
}
Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections are associated with unsafe injection practices, drug diversion, and other exposures to blood and are difficult to detect and investigate. Here, we developed and validated a simple approach for molecular detection of HCV transmissions in outbreak settings. We obtained sequences from the HCV hypervariable region 1 (HVR1), using end-point limiting-dilution (EPLD… CONTINUE READING
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