Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model

@inproceedings{Wang2017AccurateDN,
  title={Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model},
  author={Sheng Wang and Siqi Sun and Zhen Li and Renyu Zhang and Jinbo Xu},
  booktitle={PLoS Computational Biology},
  year={2017}
}
MOTIVATION Protein contacts contain key information for the understanding of protein structure and function and thus, contact prediction from sequence is an important problem. Recently exciting progress has been made on this problem, but the predicted contacts for proteins without many sequence homologs is still of low quality and not very useful for de novo structure prediction. METHOD This paper presents a new deep learning method that predicts contacts by integrating both evolutionary… CONTINUE READING
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