Accuracy of in vivo aminoacylation requires proper balance of tRNA and aminoacyl-tRNA synthetase.

@article{Swanson1988AccuracyOI,
  title={Accuracy of in vivo aminoacylation requires proper balance of tRNA and aminoacyl-tRNA synthetase.},
  author={Robert S. Swanson and Patricia J. Hoben and Martin Sumner-Smith and Haruki Uemura and Lillian Watson and Dieter S{\"o}ll},
  journal={Science},
  year={1988},
  volume={242 4885},
  pages={1548-51}
}
The fidelity of protein biosynthesis in any cell rests on the accuracy of aminoacylation of tRNA. The exquisite specificity of this reaction is critically dependent on the correct recognition of tRNA by aminoacyl-tRNA synthetases. It is shown here that the relative concentrations of a tRNA and its cognate aminoacyl-tRNA synthetase are normally well balanced and crucial for maintenance of accurate aminoacylation. When Escherichia coli Gln-tRNA synthetase is overproduced in vivo, it incorrectly… CONTINUE READING

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