Accuracy of clinical diagnosis of Parkinson disease

@article{Rizzo2016AccuracyOC,
  title={Accuracy of clinical diagnosis of Parkinson disease},
  author={Giovanni Rizzo and Massimiliano Copetti and Simona Arcuti and Davide Martino and Andrea Fontana and Giancarlo Logroscino},
  journal={Neurology},
  year={2016},
  volume={86},
  pages={566 - 576}
}
OBJECTIVE To evaluate the diagnostic accuracy of clinical diagnosis of Parkinson disease (PD) reported in the last 25 years by a systematic review and meta-analysis. [...] Key MethodWe searched for articles published between 1988 and August 2014. Studies were included if reporting diagnostic parameters regarding clinical diagnosis of PD or crude data. The selected studies were subclassified based on different study setting, type of test diagnosis, and gold standard.Expand
Gait Analysis in Parkinson’s Disease: An Overview of the Most Accurate Markers for Diagnosis and Symptoms Monitoring
The aim of this review is to summarize that most relevant technologies used to evaluate gait features and the associated algorithms that have shown promise to aid diagnosis and symptom monitoring inExpand
Accuracy of clinical diagnosis of Parkinson disease: A systematic review and meta-analysis
Editors' Note: In WriteClick this week, Dr. Jellinger reports an analysis of a 50-year series of 604 patients clinically diagnosed with Parkinson disease and later confirmed via autopsy, and findsExpand
Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases
TLDR
Over 90% of cases clinically diagnosed as early PD fulfilled the MDS criteria for PD, and those not fulfilling criteria may have an atypical parkinsonian disorder or secondary parkinsonism that is not correctly identified by the UK Brain Bank criteria, but possibly by the new criteria. Expand
Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series
TLDR
Both a clinical diagnosis of Parkinson’s disease as well as MDS-PD criteria accurately predicted presence of LP in NBB donors, and LP was associated with more widespread amyloid-β pathology, suggesting a link between amyloids-β accumulation and LP formation. Expand
Diagnostic Criteria for Parkinson’s Disease: From James Parkinson to the Concept of Prodromal Disease
TLDR
This paper critically re-appraise the main diagnostic criteria proposed for PD, with particular attention to the recently published criteria by the International Parkinson and Movement Disorder Society (MDS) task force, underlying their novelty and focusing on the diagnostic issues still open. Expand
Accuracy of Transcranial Sonography of the Substantia Nigra for Detection of Parkinson's Disease: A Systematic Review and Meta-analysis.
TLDR
This meta-analysis revealed the high diagnostic performance of TCS in differentiating patients with PD from both normal controls and participants with other parkinsonian syndromes. Expand
Neuropathological correlation supports automated image-based differential diagnosis in parkinsonism
TLDR
An automated image-based algorithm to discriminate between IPD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) agreed well with autopsy and can help to improve diagnostic accuracy during the period of clinical uncertainty. Expand
Nuclear Imaging in the Diagnosis of Clinically Uncertain Parkinsonian Syndromes.
TLDR
DAT-SPECT has been well documented to be highly diagnostically accurate and to have a relevant influence on the diagnosis and treatment of patients with clinically uncertain parkinsonian or tremor syndrome, but it has not yet been shown to improve patient-relevant endpoints such as mortality, morbidity, and health-related quality of life. Expand
The New Diagnostic Criteria for Parkinson's Disease.
TLDR
This chapter summarizes the advances in diagnosis of Parkinson's disease that were encapsulated in new International Parkinson Disease and Movement Disorders Society diagnostic criteria for PD, which includes a clinicogenetic subtype of PD and relies upon published studies of PD predictors to calculate the probability that any individual will develop PD. Expand
Impact of DaTscan Imaging on Clinical Decision Making in Clinically Uncertain Parkinson’s Disease
TLDR
DaTscan imaging can be useful in several clinical scenarios to determine if NSDD is present, including in patients with early subtle symptoms, suboptimal response to levodopa, prominent action tremor, drug-induced parkinsonism, and in Patients with lower extremity or other less common parkinsonist clinical presentations. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
Low clinical diagnostic accuracy of early vs advanced Parkinson disease
TLDR
This study establishes the novel findings of only 26% accuracy for a clinical diagnosis of PD in untreated or not clearly responsive subjects, 53% accuracy in early PD responsive to medication (<5 years' duration), and >85% diagnostic accuracy of longer duration, medication-responsive PD. Expand
The evolution of diagnosis in early Parkinson disease. Parkinson Study Group.
TLDR
65 (8.1%) of patients initially diagnosed as having PD were later found to have an alternate diagnosis based on multifactorial clinical diagnostic criteria, indicating that experts in PD changed their diagnoses infrequently during the 7.6-year follow-up. Expand
Diagnostic accuracy of parkinsonism syndromes by general neurologists.
TLDR
Parkinson's disease is heavily overdiagnosed by general neurologists, whereas parkinsonism plus syndromes are underdiagnosed. Expand
What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study
TLDR
Assessment of clinical features of 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease suggests that studies based on consultant diagnosis of PD, using standard diagnostic criteria, will include cases other than PD, thus distorting results from clinical trials and epidemiologic studies. Expand
Accuracy of clinical diagnosis in parkinsonism--a prospective study.
TLDR
The correct clinical diagnosis in most non-IPD variants of PS was possible within 5 years of onset (range: 2 months to 18 years), and it is recommended that studies aimed at including only the IPD cases restrict the enrollment to those cases that have had PS motor manifestations for five years or longer duration. Expand
The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service.
TLDR
The clinical and pathological diagnoses of 143 cases of parkinsonism seen by neurologists associated with the movement disorders service at The National Hospital for Neurology and Neurosurgery in London suggest that neurologists with particular expertise in the field of movement disorders may be using a method of pattern recognition for diagnosis which goes beyond that inherent in any formal set of diagnostic criteria. Expand
Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT
TLDR
On‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. Expand
How valid is the clinical diagnosis of Parkinson's disease in the community?
TLDR
At least 15% of patients with a diagnosis of Parkinson's disease in the population do not fulfil strict clinical criteria for the disease, and approximately 20% of Patients with Parkinson's Disease who have already come to medical attention have not been diagnosed as such. Expand
Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study.
  • K. Jellinger
  • Medicine
  • Journal of neural transmission. Supplementum
  • 2007
TLDR
Clinico-pathological studies in DBL, demented and nondemented PD, and AD cases showed a negative relation between cognitive impairment and Alzheimer changes, suggesting that these either alone or in combination with cortical Lewy body pathologies are major causes of cognitive dysfunction. Expand
Changes in diagnosis with follow-up in an incident cohort of patients with parkinsonism
TLDR
The clinical diagnosis of the cause of parkinsonism at presentation was often incorrect, even when made by those with a special interest, and Parkinson’s disease was overdiagnosed. Expand
...
1
2
3
4
5
...