Accuracy of Serologic Tests and HLA-DQ Typing for Diagnosing Celiac Disease

@article{Hadithi2007AccuracyOS,
  title={Accuracy of Serologic Tests and HLA-DQ Typing for Diagnosing Celiac Disease},
  author={Muhammed Hadithi and B. Mary E. von Blomberg and J. Bart A. Crusius and Elisabeth Bloemena and Piet J. Kostense and Jos W. R. Meijer and Chris J.J. Mulder and Coen D. A. Stehouwer and A. S. Pea},
  journal={Annals of Internal Medicine},
  year={2007},
  volume={147},
  pages={294-302}
}
Context The value of adding HLA genetic typing to serologic testing for celiac disease is not well defined. Contribution In this prospective study of patients referred for evaluation of celiac disease, the test performance of combinations of genetic typing and serologic testing was similar to that of either strategy alone. Caution The small number of cases of celiac disease precluded meaningful comparisons of testing strategies. Implications The combination of genetic typing and serologic… 
Utility of testing patients, on presentation, for serologic features of celiac disease.
Testing for gluten-related disorders in clinical practice: the role of serology in managing the spectrum of gluten sensitivity.
TLDR
Serological testing can be used to identify symptomatic individuals that need a confirmatory biopsy, to screen at-risk populations or to monitor diet compliance in patients previously diagnosed with celiac disease, Thus, interpretation of serological testing requires consideration of the full clinical scenario.
Clinical Utility of Celiac Disease-Associated HLA Testing
TLDR
Assessment of the performance of HLA testing when applied to patient groups with varying characteristics and proposed evidence-based recommendations for its clinical use finds it is a practical and valuable test for most patients in whom initial evaluation for CD is inconclusive.
The potential usefulness of human leukocyte antigen typing for celiac disease screening: A systematic review and meta-analysis.
TLDR
Due to its great sensitivity and low negative likelihood ratio, human leukocyte antigen-DQ2/DQ8 typing would be an appropriate test for ruling out celiac disease in the general population suffering related symptoms, and even more in at risk population.
Evaluation of Multiple Diagnostic Indicators in Comparison to the Intestinal Biopsy as the Golden Standard in Diagnosing Celiac Disease in Children
TLDR
The presented methodology predicted a correct classification in more than 90% of the cases, and the single best predictors were antibodies (i.e., anti-endomysium immunoglobulin A (IgA) (EMA) and transglutaminase IgA (TGA)), followed by HLA-type and nitric oxide (NO)-metabolites.
A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways
TLDR
Screening with TG2 IgA serology and requiring biopsy confirmation caused the community prevalence of CD to be substantially underestimated, and testing for HLA-DQ genes and confirmatory serology could reduce the numbers of unnecessary gastroscopies.
Serological testing for celiac disease in adults
TLDR
DGP and tTG for serological testing for CD show equivalent diagnostic performance and HLA typing to exclude CD may still be controversial, but it still seems premature to diagnose celiac disease in adults based on serology alone.
Transglutaminase IgA Antibodies in a Celiac Disease Mass Screening and the Role of HLA-DQ Genotyping and Endomysial Antibodies in Sequential Testing
TLDR
TTG-IgA is a robust marker when used in CD mass screening and its performance can be enhanced by sequential testing for EMA or HLA-DQ genotyping, which would reduce the number of negative small intestinal biopsies.
HLA-DQ Typing Kits in Diagnosis and Screening for Celiac Disease.
TLDR
Three different HLA-DQ typing kits are compared for their performance, utilization, and costs and it is found that all kits correctly identify the CD risk genes.
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