Accuracy of Rapid and Point-of-Care Screening Tests for Hepatitis C

  title={Accuracy of Rapid and Point-of-Care Screening Tests for Hepatitis C},
  author={S Chengti Shivkumar and Rosanna W. Peeling and Yalda Jafari and Lawrence Joseph and Nitika Pant Pai},
  journal={Annals of Internal Medicine},
  pages={558 - 566}
BACKGROUND 170 million persons worldwide are infected with hepatitis C, many of whom are undiagnosed. Although rapid diagnostic tests (RDTs) and point-of-care tests (POCTs) provide a time- and cost-saving alternative to conventional laboratory tests, their global uptake partly depends on their performance. PURPOSE To meta-analyze the diagnostic accuracy of POCTs and RDTs to screen for hepatitis C. DATA SOURCES MEDLINE, EMBASE, BIOSIS, and Web of Science (1992 to 2012) and bibliographies of… 

Impact of rapid point‐of‐care screening tests for the identification of chronic hepatitis C infection

Data suggest that POCTs of blood (serum, plasma, or whole blood) have the highest accuracy, followed by RDTs of serum or plasma and POCTS of oral fluids, which may be useful in expanding first-line screening for hepatitis C.

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Diagnostic Accuracy of Point-of-Care Tests for Hepatitis C Virus Infection: A Systematic Review and Meta-Analysis

OraQuick had the highest test sensitivity and specificity and showed better performance than a third generation enzyme immunoassay in seroconversion panels and the next highest test sensitivities and specificities were from TriDot and SDBioline, followed by Genedia and Chembio.

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The POCTs evaluated in this study showed high sensitivity and specificity, with no change in the performance after the third minute of reading, compared to the chemiluminescence.

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RDTs, including oral tests, have excellent sensitivity and specificity compared to laboratory-based methods for HCV antibody detection across a wide range of settings.

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A number of RDT may be suitable for WHO prequalification and may be implemented in the framework of large-scale low-cost treatment programs to achieve the WHO viral hepatitis objectives by 2030.

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A systematic review of the accuracy of antibody tests compared with other immunoassays and RNA detection for screening asymptomatic adults for HCV infection in Canada suggested that there was a high concern for risk of bias, particularly verification bias, and substantial inconsistency between studies in terms of their design.



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Rapid anti- HCV tests can provide sensitive and specific anti-HCV results for high-risk patients and are associated with human immunodeficiency virus positivity for both approaches for Chembio and MedMira.

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OraQuick's accuracy is comparable to the EIA and could help HCV screening programs reach individuals unaware of their status and expand testing into nonclinical settings such as mobile units.

Rapid and simple point of care diagnostics for STIs

The high prevalence of asymptomatic gonococcal and chlamydial infections is one of the greatest obstacles to STI control, especially in developing countries, where partner notification is difficult.

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SM-HCV Rapid Test is a reliable test with high sensitivity and specificity for the detection of antibody to hepatitis C virus with reference to the well-established third generation enzyme immunoblot assay EIA-3.

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All the rapid/simple tests were easy to perform and interpret, required no (or minimal) laboratory equipment, and could be taught easily to local laboratory personnel.

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Comparison results in detection of HCV antibodies by using GLD HCV-SPOT, ELISA and GLD/DBL HCV BLOT are reported.