Accuracy of Rapid and Point-of-Care Screening Tests for Hepatitis C

@article{Shivkumar2012AccuracyOR,
  title={Accuracy of Rapid and Point-of-Care Screening Tests for Hepatitis C},
  author={S Chengti Shivkumar and Rosanna W. Peeling and Yalda Jafari and Lawrence Joseph and Nitika Pant Pai},
  journal={Annals of Internal Medicine},
  year={2012},
  volume={157},
  pages={558 - 566}
}
BACKGROUND 170 million persons worldwide are infected with hepatitis C, many of whom are undiagnosed. Although rapid diagnostic tests (RDTs) and point-of-care tests (POCTs) provide a time- and cost-saving alternative to conventional laboratory tests, their global uptake partly depends on their performance. PURPOSE To meta-analyze the diagnostic accuracy of POCTs and RDTs to screen for hepatitis C. DATA SOURCES MEDLINE, EMBASE, BIOSIS, and Web of Science (1992 to 2012) and bibliographies of… Expand
Impact of rapid point‐of‐care screening tests for the identification of chronic hepatitis C infection
TLDR
Data suggest that POCTs of blood (serum, plasma, or whole blood) have the highest accuracy, followed by RDTs of serum or plasma and POCTS of oral fluids, which may be useful in expanding first-line screening for hepatitis C. Expand
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Tests with better analytical sensitivity need to been developed and their feasibility and outcomes in various clinical settings need to be addressed. Expand
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  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2016
TLDR
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Diagnostic Performance of Two Point-of-Care Tests for Anti-HCV Detection
TLDR
The POCTs evaluated in this study showed high sensitivity and specificity, with no change in the performance after the third minute of reading, compared to the chemiluminescence. Expand
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TLDR
RDTs, including oral tests, have excellent sensitivity and specificity compared to laboratory-based methods for HCV antibody detection across a wide range of settings. Expand
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TLDR
HCV-Ab and HBsAg testing using DBS compared to venous blood sampling was associated with excellent diagnostic accuracy, however, generalizability is limited as no uniform protocol was applied and most studies did not use fresh samples. Expand
Performance of rapid diagnostic tests for HCV infection in serum or plasma.
TLDR
A number of RDT may be suitable for WHO prequalification and may be implemented in the framework of large-scale low-cost treatment programs to achieve the WHO viral hepatitis objectives by 2030. Expand
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