Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites.

@article{Wong2004AccuracyAP,
  title={Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites.},
  author={Wendy S. W. Wong and Ziheng Yang and N. Goldman and R. Nielsen},
  journal={Genetics},
  year={2004},
  volume={168 2},
  pages={1041-51}
}
The parsimony method of Suzuki and Gojobori (1999) and the maximum likelihood method developed from the work of Nielsen and Yang (1998) are two widely used methods for detecting positive selection in homologous protein coding sequences. Both methods consider an excess of nonsynonymous (replacement) substitutions as evidence for positive selection. Previously published simulation studies comparing the performance of the two methods show contradictory results. Here we conduct a more thorough… CONTINUE READING
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