Accuracy and Power of the Likelihood Ratio Test for Comparing Evolutionary Rates Among Genes

@article{Aagaard2004AccuracyAP,
  title={Accuracy and Power of the Likelihood Ratio Test for Comparing Evolutionary Rates Among Genes},
  author={Jan Erik Aagaard and Patrick Phillips},
  journal={Journal of Molecular Evolution},
  year={2004},
  volume={60},
  pages={426-433}
}
Sequences for multiple protein-coding genes are now commonly available from several, often closely related species. These data sets offer intriguing opportunities to test hypotheses regarding whether different types of genes evolve under different selective pressures. Although maximum likelihood (ML) models of codon substitution that are suitable for such analyses have been developed, little is known about the statistical properties of these tests. We use a previously developed fixed-sites… CONTINUE READING

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