Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression

  title={Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression},
  author={Yasuhiro Ono and Takashi Tamiya and Tomotsugu Ichikawa and Kengo Matsumoto and Tomohisa Furuta and Takashi Ohmoto and Kosuke Akiyama and S. Louise Seki and Keisuke Ueki and David N Louis},
  journal={Acta Neuropathologica},
Approximately one quarter of human astrocytomas show immunohistochemical positivity for p53 protein but lack p53 gene mutations, which could reflect either an accumulation of wild-type p53 protein or an inadequate sensitivity of mutation detection. Since wild-type p53 up-regulates p21 expression, increased p21 expression in those astrocytomas with p53 accumulation in the absence of mutations would argue that the protein was wild type in these tumors. We therefore compared p21 expression with… CONTINUE READING
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