Accumulation of topically applied porcine insulin in the retina and optic nerve in normal and diabetic rats.

@article{Koevary2002AccumulationOT,
  title={Accumulation of topically applied porcine insulin in the retina and optic nerve in normal and diabetic rats.},
  author={Steven B Koevary and Jennifer Nussey and Stephen Lake},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 3},
  pages={797-804}
}
PURPOSE To explore the pharmacokinetics of topical insulin administration in relation to retinal and optic nerve retention. METHODS Insulin eye drops (approximately 15 microL: 0.75% porcine insulin + 0.5% permeation enhancer) were applied to the eyes of normal and diabetic rats. The rats were killed at various intervals up to 16 hours, and the retinas and optic nerves from both eyes were analyzed for the presence of insulin in an ELISA. The extent to which systemically absorbed insulin… CONTINUE READING