Accumulation of the pro-apoptotic factor Bak is controlled by antagonist factor Mcl-1 availability

@article{Minet2006AccumulationOT,
  title={Accumulation of the pro-apoptotic factor Bak is controlled by antagonist factor Mcl-1 availability},
  author={Emmanuel Minet and J.-P. Cosse and Catherine Demazy and Martine Raes and Carine Michiels},
  journal={Apoptosis},
  year={2006},
  volume={11},
  pages={1039-1047}
}
Apoptosis has become recognized as a crucial mechanism involved in a wide range of physiological and pathological processes. Following an initial pro-apoptotic signal, controlling phases allow the cell to reinforce or downgrade signals leading to the irrevocable entry into apoptosis. Bak (Bcl-2-antagonist killer) is a mitochondrial pore-forming pro-apoptotic effector inhibited through titration by the anti-apoptotic protein Mcl-1 (Myeloid cell leukemia-1). Viruses have taken advantage of… CONTINUE READING
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