Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes

Abstract

Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular localization. Here we demonstrate that the accumulation of Tks4R43W depends on the intact microtubule network. Detergent-insoluble Tks4 mutant… (More)
DOI: 10.1186/s12964-015-0108-8

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