Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models.

@article{Ballinger2003AccumulationOT,
  title={Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models.},
  author={James R. Ballinger and Victor Hsue and A. Michael Rauth},
  journal={Nuclear medicine communications},
  year={2003},
  volume={24 5},
  pages={597-606}
}
99mTc-glucarate is an investigational radiopharmaceutical which has been shown to accumulate in acute cerebral and myocardial injuries and in some tumours. In the present work, a survey of possible factors affecting the cellular accumulation of 99mTc-glucarate was carried out in cell lines and strains in vitro and in murine tumours in vivo. Accumulation was enhanced under hypoxic conditions in 12 of the 16 human and murine cell lines and strains studied, and inhibited in the presence of… CONTINUE READING