Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.

@article{Klibanov2001AccumulationOS,
  title={Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.},
  author={S A Klibanov and Heather M O'Hagan and Mats Ljungman},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 10},
  pages={1867-73}
}
The tumor suppressor p53 is a nucleocytoplasmic shuttling protein that accumulates in the nucleus of cells exposed to various cellular stresses. One important role of nuclear p53 is to mobilize a stress response by transactivating target genes such as the p21(Waf1) gene. In this study, we investigated more closely the localization of p53 in cells following various stresses. Immunocytochemistry of fixed human fibroblasts treated with either UV light, the kinase and transcription inhibitor DRB or… CONTINUE READING

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Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research • 2000

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