Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.

  title={Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.},
  author={S A Klibanov and Heather M O'Hagan and Mats Ljungman},
  journal={Journal of cell science},
  volume={114 Pt 10},
The tumor suppressor p53 is a nucleocytoplasmic shuttling protein that accumulates in the nucleus of cells exposed to various cellular stresses. One important role of nuclear p53 is to mobilize a stress response by transactivating target genes such as the p21(Waf1) gene. In this study, we investigated more closely the localization of p53 in cells following various stresses. Immunocytochemistry of fixed human fibroblasts treated with either UV light, the kinase and transcription inhibitor DRB or… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 34 extracted citations

The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

International journal of molecular sciences • 2018
View 2 Excerpts

Targeting the nucleolus for cancer intervention.

Biochimica et biophysica acta • 2014
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 50 references

Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research • 2000

Similar Papers

Loading similar papers…