Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.

@article{Sakaguchi1995AccumulationOP,
  title={Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.},
  author={Satoru Sakaguchi and Shigeru Katamine and Kazuto Shigematsu and Akira Nakatani and Ryozo Moriuchi and Noriyuki Nishida and Ken Kurokawa and Ryota Nakaoke and Hiroyuki Sato and Kou-ichi Jishage},
  journal={Journal of virology},
  year={1995},
  volume={69 12},
  pages={7586-92}
}
Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disease of humans caused by an unidentified infectious agent, the prion. To determine whether there was an involvement of the host-encoded prion protein (PrPc) in CJD development and prion propagation, mice heterozygous (PrP+/-) or homozygous (PrP-/-) for a disrupted PrP gene were established and inoculated with the mouse-adapted CJD agent. In keeping with findings of previous studies using other lines of PrP-less mice… CONTINUE READING

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