Accumulation of prion protein in the brain that is not associated with transmissible disease.

@article{Piccardo2007AccumulationOP,
  title={Accumulation of prion protein in the brain that is not associated with transmissible disease.},
  author={Pedro Piccardo and Jean C Manson and Declan King and Bernardino Ghetti and Rona M. Barron},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 11},
  pages={4712-7}
}
Prion diseases or transmissible spongiform encephalopathies are characterized histopathologically by the accumulation of prion protein (PrP) ranging from diffuse deposits to amyloid plaques. Moreover, pathologic PrP isoforms (PrP(Sc)) are detected by immunoblot analysis and used both as diagnostic markers of disease and as indicators of the presence of infectivity in tissues. It is not known which forms of PrP are associated with infectivity. To address this question, we performed bioassays… CONTINUE READING

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