Accumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans in liver of control laboratory rats.

@article{Heuvel1994AccumulationOP,
  title={Accumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans in liver of control laboratory rats.},
  author={John Patrick Vanden Heuvel and George C. Clark and A m Tritscher and George W. Lucier},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1994},
  volume={23 3},
  pages={465-9}
}
Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls belong to a class of compounds, the polyhalogenated aromatic hydrocarbons (PHAHs), which are ubiquitous environmental contaminants. Due to the existence of a common mechanism of action, i.e., binding to the Ah receptor, the activity of members of this class of compounds is generally expressed relative to the prototypical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as toxic equivalency factors (TEFs). In the present… CONTINUE READING