Accumulation of pathogenic prion protein (PrPSc) in nervous and lymphoid tissues of sheep with subclinical scrapie.

@article{Ersdal2003AccumulationOP,
  title={Accumulation of pathogenic prion protein (PrPSc) in nervous and lymphoid tissues of sheep with subclinical scrapie.},
  author={C Ersdal and Martha Jakobsen Ulvund and Sylvie L. Benestad and Michael A Tranulis},
  journal={Veterinary pathology},
  year={2003},
  volume={40 2},
  pages={164-74}
}
All sheep older than 1 year of age from a flock of the Rygja breed in which clinical scrapie was detected for the first time in two animals (4%) were examined for accumulation of pathogenic prion protein (PrPSc) by immunohistochemistry in the obex, the cerebellum, and the medial retrophayngeal lymph node. In addition, six lambs, 2-3 months old, all offspring of PrPSc-positive dams, were examined for PrPSc in the ileal Peyers' patch (IPP), the distal jejunal lymph node, the spleen, and the… CONTINUE READING

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