Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis.

Abstract

Up to now the possible involvement of p53 in rodent cancerogenesis has been based on results of the endpoint of chemically or virally induced carcinogenesis-tumors. To address the role of altered p53 expression in different stages of the multi-step process of rodent carcinogenesis in a systematic way we fed potent chemical carcinogens to male rats for 6… (More)

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