• DOI:10.1016/j.brainres.2012.04.001
Corpus ID: 23744888

Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders

@article{Zhang2012AccumulationON,
  title={Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders},
  author={Yulin Zhang and Meixia Wang and Hongjun Li and Honghai Zhang and Ying Shi and F. Wei and Dao-jie Liu and Kai Liu and Dexi Chen},
  journal={Brain Research},
  year={2012},
  volume={1458},
  pages={1-11}
}

• Yulin Zhang, Meixia Wang, +6 authors Dexi Chen
• Published 2012
• Medicine, Biology
• Brain Research

Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions in DNA and RNA is 8-hydroxydeoxyguanosine (8-oxoG). Here, we studied accumulated DNA oxidative damage induced by ROS in the central nervous system (CNS) in tissue from neuro-AIDS… Expand