Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders
@article{Zhang2012AccumulationON, title={Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders}, author={Yulin Zhang and Meixia Wang and Hongjun Li and Hong-hai Zhang and Ying Shi and Feili Wei and Dao-jie Liu and Kai Liu and Dexi Chen}, journal={Brain Research}, year={2012}, volume={1458}, pages={1-11} }
61 Citations
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HIV-associated neurocognitive disorders (HAND) affect up to 50% of HIV-infected adults despite potent viral suppression with antiretroviral therapy (ART) and are associated with persistent neuronal damage, monocyte/macrophage activation, chronic inflammation, and oxidative stress and loss of HO-1 and its protective functions may contribute to HIV neuropathogenesis.
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The current state of knowledge about the involvement of oxidative stress mechanisms and role of HIV-induced ROS in the development of HAND is summarized and crucial HIV-1 pathogenicity factors implicated in neurotoxicity and inflammation are examined in order to identify molecular pathways that could serve as potential therapeutic targets for treatment of this disease.
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