Accumulation of nonesterified fatty acids causes the sustained energetic deficit in kidney proximal tubules after hypoxia-reoxygenation.

@article{Feldkamp2006AccumulationON,
  title={Accumulation of nonesterified fatty acids causes the sustained energetic deficit in kidney proximal tubules after hypoxia-reoxygenation.},
  author={Thorsten Feldkamp and Andreas Kribben and Nancy F. Roeser and Ruth A. Senter and Joel M. Weinberg},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={290 2},
  pages={F465-77}
}
Kidney proximal tubules exhibit decreased ATP and reduced, but not absent, mitochondrial membrane potential (Deltapsi(m)) during reoxygenation after severe hypoxia. This energetic deficit, which plays a pivotal role in overall cellular recovery, cannot be explained by loss of mitochondrial membrane integrity, decreased electron transport, or compromised F1F0-ATPase and adenine nucleotide translocase activities. Addition of oleate to permeabilized tubules produced concentration-dependent… CONTINUE READING