Accumulation of mitochondrial DNA mutation with colorectal carcinogenesis in ulcerative colitis

Abstract

We recently reported that oxidative stress elicited by chronic inflammation increases the mutation of mitochondrial DNA (mtDNA) and possibly correlates with precancerous status. Since severe oxidative stress is elicited in the colorectal mucosa of individuals with ulcerative colitis (UC), the possible occurrence of an mtDNA mutation in the inflammatory… (More)
DOI: 10.1038/sj.bjc.6602664

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