Accumulation of metformin by tissues of the normal and diabetic mouse.

  title={Accumulation of metformin by tissues of the normal and diabetic mouse.},
  author={Christopher C. Wilcock and Clifford J Bailey},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={24 1},
1. Tissue accumulation of the antihyperglycaemic agent metformin (dimethylbiguanide) was examined after oral administration to the normal and streptozotocin (STZ) diabetic mouse. 2. Metformin (50 mg/kg body weight containing 14C-metformin 25 microCi/kg body weight), which is stable and not metabolized, resulted in maximum plasma concentrations at 0.5 h which declined to < 5% of maximum by 24 h. Maximum plasma concentrations (mumol/l, mean +/- SE) in the hepatic portal vein (normal 51.7 +/- 5.4… CONTINUE READING
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