Accumulation of m-iodobenzylguanidine by neuroblastoma cells results from independent uptake and storage mechanisms.

@article{Montaldo1991AccumulationOM,
  title={Accumulation of m-iodobenzylguanidine by neuroblastoma cells results from independent uptake and storage mechanisms.},
  author={Paolo Giuseppe Montaldo and Marina Lanciotti and A Casalaro and Paolo Cornaglia-Ferraris and Maurilio Ponzoni},
  journal={Cancer research},
  year={1991},
  volume={51 16},
  pages={4342-6}
}
The modalities of uptake and storage of iodine-labeled m-iodobenzylguanidine (MIBG) by four human neuroblastoma cell lines have been studied. SK-N-BE(2)C cell line has been shown to possess the specific (type 1) MIBG uptake, as well as an efficient extravesicular storage mechanism. Conversely, LAN-5 cells, which show a nonsaturation kinetic of MIBG incorporation, lack only the ability to efficiently store the MIBG taken up by a mechanism that can be pharmacologically defined as uptake 1. The… CONTINUE READING

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