Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.

@article{Alexandre2006AccumulationOH,
  title={Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.},
  author={J{\'e}r{\^o}me Alexandre and Fr{\'e}d{\'e}ric Batteux and Carole Nicco and Christiane Ch{\'e}reau and Alexis Laurent and L{\"o}ic Guillevin and Bernard Weill and François Goldwasser},
  journal={International journal of cancer},
  year={2006},
  volume={119 1},
  pages={41-8}
}
Intracellular events following paclitaxel binding to microtubules that lead to cell death remain poorly understood. Because reactive oxygen species (ROS) are involved in the cytotoxicity of anticancer agents acting through independent molecular targets, we explored the role of ROS in paclitaxel cytotoxicity. Within 15 min after in vitro exposure of A549 human lung cancer cells to paclitaxel, a concentration-dependent intracellular increase in O(o)(2)(-) and H(2)O(2) levels was detected by… CONTINUE READING