Accumulation of genetic defects during astrocytoma progression.

  title={Accumulation of genetic defects during astrocytoma progression.},
  author={Webster K Cavenee},
  volume={70 6 Suppl},
BACKGROUND The development of human cancer generally is thought to entail a series of events that cause a progressively more malignant phenotype. This hypothesis predicts that tumor cells of the ultimate stage will carry each of the events; cells of the penultimate stage will carry each of the events minus the last one; and so on. Therefore, a dissection of the pathway from a normal cell to a fully malignant tumor may be viewed as the unraveling of a nested set of aberrations. METHODS In… CONTINUE READING
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