Accumulation of endogenous peptides triggers a pathogen stress response in Arabidopsis thaliana.

@article{Kmiec2018AccumulationOE,
  title={Accumulation of endogenous peptides triggers a pathogen stress response in Arabidopsis thaliana.},
  author={Beata Kmiec and Rui Mamede Branca and Oliver Berkowitz and Lu Li and Yan Wang and Monika W. Murcha and James Whelan and Janne Lehti{\"o} and Elzbieta Glaser and Pedro F Teixeira},
  journal={The Plant journal : for cell and molecular biology},
  year={2018},
  volume={96 4},
  pages={
          705-715
        }
}
The stepwise degradation of peptides to amino acids in plant mitochondria and chloroplasts is catalyzed by a network of oligopeptidases (presequence protease PreP, organellar oligopeptidase OOP) and aminopeptidases. In the present report, we show that the lack of oligopeptidase activity in Arabidopsis thaliana results in the accumulation of endogenous free peptides, mostly of chloroplastic origin (targeting peptides and degradation products). Using mRNA sequencing and deep coverage proteomics… 
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The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.
TLDR
Results show that disassembly or degradation of Complex I plays a role in determining its steady-state abundance and thus turnover may vary under different conditions.
A Mitochondrial LYR Protein Is Required for Complex I Assembly1[OPEN]
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Yeast-two-hybrid interaction and complementation assays indicate that CIAF1 specifically interacts with the 23-kD TYKY-1 matrix domain subunit of Complex I and likely plays a role in Fe-S insertion into this subunit.
Open questions on the mitochondrial unfolded protein response
TLDR
This viewpoint describes the current knowledge and understanding of protective pathways in mitochondrial homeostasis, and addresses open questions and perspectives in the field of mitochondrial stress responses.
Undegraded peptides in organelles convey toxic signals.
  • S. McCormick
  • Engineering
    The Plant journal : for cell and molecular biology
  • 2018

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