Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.

@article{Tse2005AccumulationOD,
  title={Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.},
  author={Shirley M L Tse and David P. Mason and Roberto J Botelho and Basil Chiu and Mary E. Reyland and Kentaro Hanada and Robert D. Inman and Sergio Grinstein},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={25210-5}
}
Intracellular pathogens have developed strategies to survive for extended periods inside their host cells. These include avoidance of host microbicidal effectors, often by sequestration in a protected subcompartment of the host cell. In some cases, the parasites exert also an antiapoptotic effect that prolongs the life of the infected host cell. Chlamydia utilizes both strategies, but the underlying molecular mechanisms are incompletely understood. Comparatively, little is known regarding the… CONTINUE READING

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