Accumulation of calcium and phosphate stimulated by carboxylic antibiotics into mitochondria.


Carboxylic ionophores such as nigericin, dianemycin, the monensins and compounds Lilly A217 or X-537 A, stimulate an electron-transport dependent accumulation of Ca 2§ and phosphate into mitochondria. Ion accumulation is stimulated under conditions of limited Ca 2§ loading imposed by phosphate in the presence of/3-hydxoxybutyrate. Carboxylic ionophores do… (More)


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