Accumulation of brown pigment-laden macrophages associated with vascular lesions in the lungs of cynomolgus monkeys(Macaca fascicularis)

@article{Yamakawa2016AccumulationOB,
  title={Accumulation of brown pigment-laden macrophages associated with vascular lesions in the lungs of cynomolgus monkeys(Macaca fascicularis)},
  author={Yoshika Yamakawa and Tetsuya Ide and Hikaru Mitori and Yuji Oishi and Masahiro Matsumoto},
  journal={Journal of Toxicologic Pathology},
  year={2016},
  volume={29},
  pages={181 - 184}
}
Accumulation of macrophages containing brown pigments in the lungs is a well-known spontaneous lesion found in cynomolgus monkey. However, its pathogenesis has not been clearly described. In our survey, brown pigment-laden macrophages were found in the lungs of 4 out of 43 cases. Brown pigments were mostly found in the macrophages of the perivascular interstitium, which proved to be hemosiderin. Some small- to medium-sized vessels that exhibited prominent accumulation of brown pigment-laden… 

Figures and Tables from this paper

References

SHOWING 1-8 OF 8 REFERENCES

Histopathology of Incidental Findings in Cynomolgus Monkeys (Macaca Fascicularis) Used in Toxicity Studies

The normal features of the cyclic changes of the female genital organs are presented and more information on spontaneous findings in cynomolgus monkeys for exact diagnoses in toxicity studies is provided.

Incidences and Range of Spontaneous Findings in Control Cynomolgus Monkeys (Macaca fascicularis) Used in Toxicity Studies

The authors performed a retrospective study to determine the incidences and range of spontaneous pathology findings in control cynomolgus monkeys and hoped that the results presented here and elsewhere could form the groundwork for the creation of a reliable database of incidental pathology found in laboratory nonhuman primates.

RESPIRATORY DISEASES

The author acknowledges that it is impossible, with ordinary histological methods, to distinguish between an abnormal epidermic cell and an epithelial cell which has spread into the epidermis from elsewhere, but denies it in his summaries and conclusions, which weakens his thesis considerably.

Jubb, Kennedy, and Palmer's pathology of domestic animals

The diagnostic process is described in detail in volume two, which focuses on the examination of the skin and appendages in relation to the genital system.

Respiratory system.

The respiratory system of animals includes the lungs and the passages that provide transportation of air into the lungs, which are made up of organs that deliver oxygen to the circulatory system for transport to the cells in the animal’s body.

Spontaneous lesions in cynomolgus monkeys used in toxicity studies.

Spontaneous lesions in wild-caught, laboratory-maintained cynomolgus monkeys used in drug-toxicity studies were examined histopathologically in an effort to better distinguish toxic changes from