Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion.


Cells undergo replicative senescence during in vitro expansion, which is induced by the accumulation of cellular damage caused by excessive reactive oxygen species. In this study, we investigated whether long-term-cultured human bone marrow mesenchymal stromal cells (MSCs) are insensitive to apoptotic stimulation. To examine this, we established replicative… (More)
DOI: 10.1002/cbf.3191


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