Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
@article{Leone1992AccumulationOA, title={Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure}, author={A. M. Leone and Salvador Moncada and Patrick Vallance and Alison L. Calver and Joe Collier}, journal={The Lancet}, year={1992}, volume={339}, pages={572-575} }
2,104 Citations
Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure.
- Biology, MedicineCardiovascular research
- 1998
Total nitric oxide production is low in patients with chronic renal disease.
- MedicineKidney international
- 2000
Twenty-four-hour urinary NOX excretion was low in CRD patients compared with controls despite similar dietary NO intake, suggesting that net endogenous NO production is decreased in renal disease.
Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure.
- Biology, MedicineCardiovascular research
- 2001
Arginine, arginine analogs and nitric oxide production in chronic kidney disease
- BiologyNature Clinical Practice Nephrology
- 2006
Because an increase in ADMA has emerged as a major independent risk factor in end-stage renal disease (and probably also in CKD), lowering ADMA concentration is a major therapeutic goal; interventions that enhance the activity of the ADMA-hydrolyzing enzyme DDAH are under investigation.
Nitric oxide in essential and renal hypertension.
- Medicine, BiologyJournal of the American Society of Nephrology : JASN
- 1994
In dialysis-dependent renal failure, the accumulation of endogenous compounds that inhibit NO synthase could exacerbate renal hypertension by inhibiting vascular and renal tubular NO synthesis and might provoke atherogenesis.
Effect of chronic renal failure on nitric oxide metabolism.
- Biology, MedicineAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
- 2001
The purpose of this review is to provide a brief overview of the effect of CRF on the bioavailability of NO substrate, L-arginine; the expression of NOS isoforms in the relevant organs; the interaction of NO with reactive oxygen species that are known to be increased in CRF, and the accumulation of uremic inhibitors of N OS.
Nitric oxide in chronic renal failure.
- BiologyKidney international
- 2005
Investigation showed an unimpaired availability of NO under baseline conditions but a profound reduction of agonist-induced endothelium-dependent vasodilatation in uremic patients, and suggested only a minor role for cytochrome-P450 2C9-dependent pathways in this context.
Nitric oxide deficiency in chronic kidney disease.
- BiologyAmerican journal of physiology. Renal physiology
- 2008
Interventions that can restore NO production by targeting these various pathways are likely to reduce the cardiovascular complications of CKD as well as slowing the rate of progression.
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension.
- Biology, MedicineHypertension
- 1997
ADMA, independently of the renal dimethylargininase content, may play a role in the pathogenesis in Dahl salt-sensitive hypertensive rats but not in SHR, and the results suggest that the systemic production of ADMA is not dependent on renal dim methylargin inase.
Indices of activity of the nitric oxide system in hemodialysis patients.
- Medicine, BiologyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
- 1999
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