Accumulation of adenosine 3′,5′ -monophosphate in slices of rat cerebral cortex induced by alpha-adrenergic agonists


Incubation of slices of rat cerebral cortex with the calcium ionophore A23187 produced small increases in the accumulation of adenosine 3′,5′-monophosphate (cyclic AMP). While low concentrations of Ca2+ ions (e.g., 200 µM) were sometimes necessary, the presence of adenosine (e.g., 50 µM) was essential; no effect of ionophore was observed when isoproterenol… (More)
DOI: 10.1007/BF00219427


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