Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

@article{Bancher1989AccumulationOA,
  title={Accumulation of abnormally phosphorylated $\tau$ precedes the formation of neurofibrillary tangles in Alzheimer's disease},
  author={C. Bancher and C. Brunner and H. Lassmann and H. Budka and K. Jellinger and G. Wiche and F. Seitelberger and I. Grundke‐Iqbal and K. Iqbal and H. Wiśniewski},
  journal={Brain Research},
  year={1989},
  volume={477},
  pages={90-99}
}
The intraneuronal accumulation of paired helical filaments in the form of neurofibrillary tangles is one hallmark of the brain pathology in Alzheimer's disease. At certain predilection sites, a small number of similar lesions are also present in the brains of the majority of aged non-demented individuals. As suggested by several studies before, these abnormal cytoskeletal structures contain determinants of microtubule-associated protein tau and ubiquitin. The present study uses a morphological… Expand
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