Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects.

Abstract

O6-Methylguanine has been measured in peripheral blood leukocytes of 14 patients during one or more cycles of treatment with procarbazine (daily treatment for 10 days) and in 12 patients during one or more cycles of treatment with dacarbazine (single dose per cycle). Adduct formation at levels up to about 0.4 fmole/microgram DNA was detected in all… (More)

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@article{Kyrtopoulos1993AccumulationOO, title={Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects.}, author={Soterios A Kyrtopoulos and Vassilis L. Souliotis and Christos Valavanis and Vassiliki A Boussiotis and Gerasimos A. Pangalis}, journal={Environmental Health Perspectives}, year={1993}, volume={99}, pages={143 - 147} }