Accumulation of O6- and 7-methylguanine in DNA of N-nitroso-N-methylbenzylamine-treated rats is restricted to non-target organs for N-nitroso-N-methylbenzylamine-induced carcinogenesis.

@article{Benthem1992AccumulationOO,
  title={Accumulation of O6- and 7-methylguanine in DNA of N-nitroso-N-methylbenzylamine-treated rats is restricted to non-target organs for N-nitroso-N-methylbenzylamine-induced carcinogenesis.},
  author={J. van Benthem and E. Vermeulen and H. Winterwerp and C. Wild and E. Scherer and L. den Engelse},
  journal={Carcinogenesis},
  year={1992},
  volume={13 11},
  pages={
          2101-5
        }
}
  • J. van Benthem, E. Vermeulen, +3 authors L. den Engelse
  • Published 1992
  • Chemistry, Medicine
  • Carcinogenesis
  • The distribution and accumulation of O6-methylguanine (O6-meGua) and 7-methylguanine (7-meGua) was investigated immunocytochemically in target and non-target tissues of rats injected twice weekly with 0.5 mg N-nitroso-N-methylbenzylamine (NMBzA)/kg for 16.5 weeks. Seventy two hours after every two or three doses, two NMBzA-treated rats and one control rat were killed. Tissue-specific cell proliferation was investigated after two injections of bromodeoxyuridine (BrdU) to rats unexposed to NMBzA… CONTINUE READING
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