Accumulation of MAC387+ macrophages in paracortical areas of lymph nodes in rhesus monkeys acutely infected with simian immunodeficiency virus.

@article{Otani1999AccumulationOM,
  title={Accumulation of MAC387+ macrophages in paracortical areas of lymph nodes in rhesus monkeys acutely infected with simian immunodeficiency virus.},
  author={Isao Otani and Kazuyasu Mori and Tetsutaro Sata and Keiji Terao and Kunio Doi and Hirofumi Akari and Yasuhiro Yoshikawa},
  journal={Microbes and infection},
  year={1999},
  volume={1 12},
  pages={977-85}
}
We investigated the histological features of lymph nodes, focusing on monocytes/macrophages, in rhesus monkeys (Macaca mulatta) acutely infected with simian immunodeficiency virus (SIV). In monkeys infected with a pathogenic SIV, SIVmac239, MAC387(+) newly blood-derived macrophages markedly increased in number at paracortical areas at 11 to 14 days postinoculation, concomitant with the peak of the primary SIV antigenemia. The MAC387(+) macrophages densely gathered around high endothelial… CONTINUE READING