Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas

@inproceedings{Roza2011AccumulationOK,
  title={Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas},
  author={Carolina Roza and Sol Castillejo and Jose A Lopez-Garcia},
  booktitle={Molecular pain},
  year={2011}
}
BackgroundModulation of M-type currents has been proposed as a new strategy for the treatment of neuropathic pain due to their role in regulating neuronal excitability. Using electrophysiological techniques we showed previously that the opening of Kv7 channels with retigabine, blocked ectopic discharges from axotomized fibers but did not alter transduction at intact skin afferents. We hypothesized that after nerve damage, accumulation of Kv7 channels in afferent fibers may increase M-type… CONTINUE READING

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