• DOI:10.1007/s10126-002-0044-7
Corpus ID: 23657226

Accumulation of H+ in Vacuoles Induced by a Marine Peptide Toxin, Theonellamide F, in Rat Embryonic 3Y1 Fibroblasts

@article{Wada2002AccumulationOH,
  title={Accumulation of H+ in Vacuoles Induced by a Marine Peptide Toxin, Theonellamide F, in Rat Embryonic 3Y1 Fibroblasts 
},
  author={S. Wada and S. Kantha and T. Yamashita and S. Matsunaga and N. Fusetani and S. Watabe},
  journal={Marine Biotechnology},
  year={2002},
  volume={4},
  pages={571-582}
}

S. Wada, S. Kantha, +3 authors S. Watabe

Published 2002

Biology, Medicine

Marine Biotechnology

The effects of theonellamide F, a marine bicyclic peptide, on vacuolar formation in cultured cells were studied. Theonellamide F induced large vacuoles in 6 types of mammalian cells. The vacuoles induced by theonellamide F in 3Y1 cells accumulated acridine orange, a fluorescent probe indicating the presence of an acidic organelle. Their disappearance following treatment with bafilomycin A1 suggests that these vacuoles contain vacuolar ATPase to maintain an acidic internal milieu, and this is… CONTINUE READING

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