Accumulation of DNA methylation is associated with tumor stage in gastric cancer.

@article{Oue2006AccumulationOD,
  title={Accumulation of DNA methylation is associated with tumor stage in gastric cancer.},
  author={Naohide Oue and Yoshitsugu Mitani and Junichi Motoshita and Shunji Matsumura and Kazuhiro Yoshida and Hiroki Kuniyasu and Hirofumi Nakayama and Wataru Yasui},
  journal={Cancer},
  year={2006},
  volume={106 6},
  pages={1250-9}
}
BACKGROUND The authors purpose in this study was to clarify the difference in terms of clinicopathologic features between gastric cancer (GC) with high numbers of DNA methylated genes and CpG island methylator phenotype (CIMP)-positive GC as originally defined. METHODS We analyzed DNA methylation of 12 tumor-related genes (hMLH1, MGMT, p16(INK4a), CDH1, RAR-beta, HLTF, RIZ1, TM, FLNc, LOX, HRASLS, HAND1) in 75 samples of GC from 75 patients, 25 samples of corresponding nonneoplastic mucosa… CONTINUE READING

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